PURPOSE: The side effects of PBs have played a role in the controversy over screening for prostate cancer.
We aimed to measure the precise incidence of post-PB infections and to show their risk factors.
METHODS: We conducted a prospective, multicenter study over a period of three months from April to June 2013 in France. All PBs performed during this period of time were included in the study. A web-based questionnaire allowed for the identification of patient characteristics, methods of performing biopsies, and post-operative infectious episodes. An external audit helped to ensure the completeness of the data. The primary outcome was the post biopsy infectious rate. A search for risk factors for infectious complications was undertaken using univariate and multivariate analyses.
RESULTS: The study included 2,718 patients. Six percent of the patients reported taking antibiotics in the previous 6 months and 7.4% of the patients had a past history of prostatitis. Recommended antibiotic prophylaxis, consisting of two fluoroquinolone tablets 2 hours before the examination for PB, was noted in 78.3% of cases. Post-biopsy sepsis was described in 76 subjects (2.8%). The predictors of post-biopsy sepsis in the multivariate analysis were non-compliance with the guidelines for antibiotic prophylaxis (OR =2.3, 95 CI [1.4-3.9] p=0.001) , antibiotic treatment in the previous 6 months (OR=2.1 (1.1-3.9) p=0.015) and the history of prostatitis (OR =1.7, 95 CI [1.2-2.4) p=0.002).
CONCLUSIONS: In this study, the incidence of post-prostate biopsy sepsis was 2.8%, and no deaths were reported. The risk factors identified in the multivariate analysis were non-compliance with antibiotic prophylaxis according to the guidelines, antibiotic treatment undertaken in the previous 6 months and past history of prostatitis.
Written by:
Bruyère F, Malavaud S, Bertrand P, Decock A, Cariou G, Doublet JD, Bernard L, Bugel H, Conquy S, Escaravage L, Sotto A, Boiteux JP, Pogu B, Rebillard X, Mongiat-Artus P, Coloby P. Are you the author?
Institution(s): See publishing journal.
Reference: J Urol. 2014 Jul 22. pii: S0022-5347(14)04035-X.
doi: 10.1016/j.juro.2014.07.086
PubMed Abstract
PMID: 25063492
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