Prostate cancer is the most common cancer type in men and is the second cause of death, due to cancer, in patients over 50, after lung cancer. Prostate specific antigen (PSA) is a widely used tumor marker for prostate cancer. Recently, PSA is discovered in non-prostatic cancer tissues in men and women raising doubts about its specificity for prostatic tissues. PSA exists in low serum level in healthy men and in higher levels in many prostate disorders, including prostatitis and prostate cancer. Thus, a supplementary tumor marker is needed to accurately diagnose the cancer and to observe the patient after treatment. Recently, soluble human leukocyte antigen-G (sHLA-G) has been introduced as a new tumor marker for different cancer types, including colorectal, breast, lung, and ovary. The present descriptive-experimental study was carried out including patients with malignant prostate tumor, patients with benign prostate tumor, and a group of health men as the control group, as judged by an oncologist as well as a pathologist. After sterile blood sampling, sHLA-G was measured by enzyme-linked immunosorbent assay in each group. The data was then analyzed using one-way ANOVA. P≤0.05 was considered as statistically significant. The results showed that the mean of sHLA-G level was high in patients. Also, it was found that there was a significant difference in sHLA serum level between the three groups. The data revealed that sHLA-G can be a novel supplementary tumor marker in addition to PSA to diagnose prostate cancer.
Anatomy & cell biology. 2017 Mar 29 [Epub]
Mohammad Hassan Heidari, Abolfazl Movafagh, Mohammad-Amin Abdollahifar, Shabnam Abdi, Mohamadreza Mashhoudi Barez, Hadi Azimi, Afshin Moradi, Amin Bagheri, Matineh Heidari, Jafar Hessam Mohseni, Maryam Tadayon, Hoda Mirsafian, Mahdi Ghatrehsamani
Department of Anatomy and Biology, Faculty of Medicine, Shahid Beheshti University, Tehran, Iran., Department of Medical Genetics, Cancer Research Center, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran., Department of Anatomical Sciences and Biology, School of Medicine, Azad University of Medical Sciences, Tehran, Iran., Department of Anatomical Sciences and Biology, Proteomics Laboratory, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Department of English Language Teaching, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Department of Pathology, Shohada Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran., Cardiac Surgery and Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran., School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Mohseni Clinical Diagnostic Laboratory, Noshahr, Iran., Department of Education Region 1 Tehran (Shemiranat), Tehran, Iran., Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia., Cellular and Molecular Biology Research Centre, Shahrekord University of Medical Sciences, Shahrekord, Iran.