Treatment for childhood genitourinary (GU) tumors such as Wilms tumor, rhabdomyosarcoma, and germ cell tumors has progressed to the point that cure can be expected in many cases.
However, survivorship is often coupled with a variety of late effects, of which subsequent neoplasms may be the most concerning if not the most life-threatening. Here, we review current literature to assess and report issues relating to subsequent neoplasms in patients with a history of childhood GU tumors, including causative factors, overall risks, the most prevalent subsequent neoplasms, and current recommendations for surveillance and screening.
Urology. 2015 Jul 29. pii: S0090-4295(15)00703-7. doi: 10.1016/j.urology.2015.07.022. [Epub ahead of print]
Johnston DL1, Bishop MW2, Hudson MM3, Giel DW4.
1 Division of Pediatric Urology, Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, Division of Pediatric Urology, Department of Urology, University of Tennessee Health Science Center, Memphis, TN.
2 Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN.
3 Division of Cancer Survivorship, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN.
4 Division of Pediatric Urology, Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, Division of Pediatric Urology, Department of Urology, University of Tennessee Health Science Center, Memphis, TN.