Interstitial cystitis/bladder pain syndrome (IC/BPS) is defined as persistent or chronic discomfort perceived to be related to the urinary bladder accompanied by urinary urgency or frequency. Pharmacotherapies used to treat IC/BPS include oral and intravesical agents. Oral therapies include amitriptyline, hydroxyzine, cyclosporine A, and pentosan polysulfate sodium (PPS), although the recent finding of pigmented maculopathy with chronic PPS is very concerning and must be discussed with patients, many of whom will choose to either come off this medicine or not even start it. Certolizumab pegol is a pharmacologic therapy that is currently in clinical development for treatment of IC/BPS symptoms.
The Urologic clinics of North America. 2022 May [Epub]
Christopher J Chermansky, Marina O Guirguis
Chief of Urology UPMC Magee Womens Hospital, 300 Halket Street, Suite 2541, Pittsburgh, PA 15213, USA. Electronic address: ., Division of Urogynecology, Department of Obstetrics and Gynecology, Magee Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA. Electronic address: https://twitter.com/@MGuirguisMD.