To describe clinical manifestations of patients with interstitial cystitis and bladder pain syndrome (IC/BPS) using a patient registry in Japan.
This retrospective cohort study utilized a patient registry supported by the Japanese Ministry of Health, Labor, and Welfare. Patients were classified as IC or BPS based on cystoscopic findings. Data on demographics, comorbidities, symptom severity, pain intensity, and bladder function were collected and we evaluated the differences in clinical characteristics between IC and BPS, and used multivariate analysis to search for additional factors that might contribute to pain.
A data set comprising 529 patients was obtained from 14 university hospitals. 66.5% of the cases were classified as IC and 33.5% as BPS. IC patients were significantly aged and female-dominant. Comorbidities such as autoimmune diseases were more prevalent in IC patients. All of the symptom severity, quality of life impairment, and bladder function were significantly worse in patients with IC. Urinary frequency and maximum voided volume on the Frequency-volume chart were 18.8 times and 15.0 times, and 160.9 and 214.1 mL, respectively. Bladder capacity under anesthesia was 293.8 and 472.6 mL, respectively. Maximum voided volume and the number of Hunner lesions were significant predictors of pain in IC patients.
The analysis revealed clinical manifestations of IC/BPS using the largest cohort in Japan. The results indicated higher age, higher female proportion, and higher symptomatic and functional severity in IC patients compared to BPS.
International journal of urology : official journal of the Japanese Urological Association. 2024 Oct 18 [Epub ahead of print]
Aya Niimi, Yoshiyuki Akiyama, Yamanishi Tomonori, Akira Furuta, Tomohiro Matsuo, Hikaru Tomoe, Hidehiro Kakizaki, Yoshihisa Matsukawa, Teruyuki Ogawa, Takahiko Mitsui, Naoya Masumori, So Inamura, Yutaka Enomoto, Akira Nomiya, Daichi Maeda, Yasuhiko Igawa, Haruki Kume, Yukio Homma
Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Continence Center, Dokkyo Medical University Hospital, Utsumomiya, Tochigi, Japan., Department of Urology, Jikei University School of Medicine, Tokyo, Japan., Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan., Department of Urology, Sayama Sougou Clinic, Sayama, Saitama, Japan., Department of Renal and Urologic Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan., Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan., Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan., Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan., Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan., Department of Urology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan., Division of Urology, Mitsui Memorial Hospital, Tokyo, Japan., Department of Urology, Japan Labour Health and Welfare Organization Kanto Rosai Hospital, Kawasaki, Kanagawa, Japan., Department of Molecular and Cellular Pathology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan., Department of Urology, Nagano Prefectural Shinshu Medical Center, Suzaka, Nagano, Japan.