Bladder pain syndrome/interstitial cystitis (BPS/IC) has various treatments; however, no standardized treatment has been established. The aim was to analyze different types of treatment of BPS/IC and their effectiveness.
A literature review with a search strategy for articles related to BPS/IC published between 1990 and 2014 was conducted on MEDLINE, PUBMED, and SCOPUS Only randomized controlled trials in women were included in the meta-analysis, while other experimental studies were used as bases for a systematic review of the topic Clinical trial quality was defined according to the Jadad scale
Of 356 articles, 13 were included in the analysis The intervention methods were as follows: instillation of hyaluronic acid, botulinum toxin A, intravesical lidocaine, hyperbaric chamber, massage, physiotherapy, phosphate-buffered saline, piroxicam in combination with doxepin, and others We did not find any treatment with at least two randomized controlled trials for meta-analysis Among the assessment tools for symptoms of BPS/IC, the most frequently used were the visual analogue scale, voiding record, and the O'Leary-Sant questionnaire
Existing studies were not able to define the best approach for the treatment of BPS/IC The lack of standardized treatment may be related to the diversity of interventions used; therefore, further studies with better methodological quality are needed
International urogynecology journal 2015 Aug 14 [Epub ahead of print]
Carolina Pazin, Andréia Moreira de Souza Mitidieri, Ana Paula Moreira Silva, Maria Beatriz Ferreira Gurian, Omero Benedicto Poli-Neto, Julio Cesar Rosa-E-Silva
Department of Gynecology and Obstetrics, Faculty of Medicine, University of São Paulo, Av Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil