Objectives: To clarify the potential role of fluid intake-to-bed time and nocturia frequency on bladder cancer risk in a hospital-based case-control study with Chinese people. Materials and Methods: Four hundred and seven patients with histologically diagnosed bladder cancer and 400 matched controls were enrolled in this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression model. Results: After adjustment for potential confounders, the fluid intake-to-bed time was associated with a decreased risk of BCa, with an OR of 0.586 (95% CI= 0.375-0.916, ≤1h) and 0.257 (95% CI= 0.162-0.407, >1h). The adjusted OR of BCa for subjects with more nocturia frequency (≥2 times) was 2.268 (95 % CI= 1.481-3474), compared to those with no nocturia. Conclusion: We suggested strong protective effect of long fluid intake-to-bed time on BCa risk, especially in ones with ≥2 times nocturia frequency. These results provide evidence for identifying high-risk individuals and modifying their behaviors and lifestyle.
Journal of Cancer. 2017 Sep 15*** epublish ***
Jianfeng Cui, Qiyu Bo, Ning Zhang, Shouzhen Chen, Meng Yu, Shiyu Wang, Jie Han, Pengxiang Chen, Dongqing Zhang, Yaofeng Zhu, Benkang Shi
Department of Urology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China., Department of First Operating Room, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China., Department of Radiation Oncology, Shandong Cancer Hospital and Institute affiliated to Shandong University, Jinan, P.R. China., Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China.