The aim of this study was to evaluate the efficacy of Pycnogenol® supplementation in terms of safety and tolerability in the setting of preclinical or borderline, initial symptoms of benign prostatic hyperthrophy (BPH), in otherwise healthy subjects, using Pycnogenol® over a period of 60 days.
Seventy-five healthy men with symptoms and signs of initial BPH were included. The subjects were divided into three groups: 1) control group using only the standard management (SM); 2) a group using SM plus Pycnogenol® 150 mg/day; 3) a group using standard pharmacological management.
BPH symptoms like emptying, frequency, intermittency, urgency, weak flow, straining, nocturia, were all significantly improved with Pycnogenol® (P<0.05) and the difference with both control groups was statistically significant (P<0.05).
Pycnogenol® may be an important option for self-management of BPH in otherwise healthy men.
Minerva medica. 2018 Aug [Epub]
Andrea Ledda, Gianni Belcaro, Beatrice Feragalli, Umberto Cornelli, Mark Dugall, Marcello Corsi, Maria R Cesarone
IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy., IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy - .