Nocturia is a common phenomenon in older individuals, and is associated with poor quality of life. Nocturia is a multifactorial disorder, wherein the frailty of skeletal muscles, particularly muscle weakness in the lower trunk and hip regions, might be a risk factor in women. We analyzed a dataset of the general Japanese population to clarify the hypothesis.
Study participants included 1207 older women (mean age 67.4 ± 5.2 years). The frequency of nocturnal urination was assessed using a sleep diary for 1 week, and associations with lower muscle strength, skeletal muscle index, sarcopenia and physical performance (one-leg standing time and Timed Up and Go test) were investigated.
The frequency of nocturnal urination more than one voiding per night was 28.1%; this frequency was inversely associated with hip abduction strength quartiles (Q1: 37.0, Q2: 30.5, Q3: 25.1 and Q4: 19.9%, P < 0.001). When a sleep diary-based nocturnal urination frequency >1.5 times/night (corresponding to a ≥2 times/night frequency obtained by questionnaire) was considered as nocturia, logistic regression analysis adjusted for major covariates identified hip abduction strength as an independent inverse determinant of nocturia (odds ratio 0.75, 95% CI 0.52-0.90, P = 0.002). In contrast, no significant association was observed with knee extension (P = 0.322) and hip flexion (P = 0.603) strengths. Physical performance, skeletal muscle index and sarcopenia did not show significant associations with nocturia.
Weak hip abduction strength might be a factor associated with nocturnal urination frequency in older women. Geriatr Gerontol Int 2019; 19: 1010-1016.
Geriatrics & gerontology international. 2019 Sep 01 [Epub]
Yasuharu Tabara, Tome Ikezoe, Takeshi Matsumoto, Kimihiko Murase, Kazuya Setoh, Satoshi Funada, Takahisa Kawaguchi, Shunsuke Nagashima, Shinji Kosugi, Toyohiro Hirai, Takeo Nakayama, Tomoko Wakamura, Kazuo Chin, Noriaki Ichihashi, Tadao Tsuboyama, Fumihiko Matsuda
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan., Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Department of Urology, Kyoto University Hospital, Kyoto, Japan., Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Kyoto, Japan., Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan.