Although epidemiological studies have found nocturia to be associated with diuretic use [1], randomized trials have shown that well-timed diuretics improve nocturia severity [2,3], suggesting that the well-described link between nocturia and mortality may be mediated by its status as a marker of volume overload states [4]. Despite their inclusion in current nocturia guidelines [5], diuretics remain underutilized in the treatment of nocturia [6], and their effect on nocturia in patients with volume overload has not been well studied.
BJU international. 2020 Jan 27 [Epub ahead of print]
Thomas F Monaghan, Fred Gong, Michael Vaysblat, Christopher D George, Kyle P Michelson, Zhan D Wu, Christina W Agudelo, Donald L Bliwise, Karel Everaert, Jeffrey P Weiss, Richard Sadovsky, Alan J Wein, Jason M Lazar
Department of Urology, State University of New York Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, New York, 11203, United States., Department of Neurology, Emory University School of Medicine, 12 Executive Park Drive, Room 435, Atlanta, Georgia, 30329, United States., Department of Urology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium., Department of Family Medicine, State University of New York Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, New York, 11203, United States., Division of Urology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard Philadelphia, Pennsylvania, 19104, United States., Department of Medicine, Division of Cardiovascular Medicine, SUNY Downstate Health Sciences University, Brooklyn, New York, 11203, United States.