To identify pathophysiological mechanisms of nocturia and the correlation of these mechanisms with nocturia severity.
After approval by the local ethics committee, all patients with nocturia (≥1 nocturnal void/night) were included and filled the overactive bladder questionnaire (OABq), nocturia quality of life (N-QoL), ICIQ-MLUTS (male), ICIQ-FLUTS (female) and 3-day frequency-volume chart. Patients were divided into three groups according the severity of nocturia: group 1 consisted of patients with mild (1-2 voids/night), group 2 with moderate (3-4 voids/night) and group 3 with severe nocturia (>4 voids/night). Comparative analysis were performed between groups, p<0.05 was deemed as statistically significant.
68.1%, 64.1% and 8.7% of the patients had nocturnal polyuria, reduced bladder capacity and global polyuria; respectively. 42.7% of the patients had mixed nocturia. 6.1% of the patients did not comply with the afore-mentioned subtypes and defined as isolated nocturia. Regarding the severity of nocturia; 155 (41%) patients had mild, 167 (45%) patients had moderate and 57 (15%) patients had severe nocturia. Increased nocturia severity was related with decreased quality of life; higher age, urinary tract symptom scores, nocturnal urine volume, evening fluid consumption and beta-blocker medication rates. Increased nocturia severity was also associated with higher nocturnal polyuria, global polyuria and reduced bladder capacity rates.
Nocturia mechanisms may vary between mild and moderate to severe nocturia groups according to the present study. Nocturia grading with identification of subtypes may help for better standardization of the diagnostic and treatment approaches as well as for the design of future clinical trials.
International journal of clinical practice. 2020 Sep 24 [Epub ahead of print]
Ozan Bozkurt, Bora Irer, Fuat Kizilay, Oguzcan Erbatu, Volkan Sen, Onder Cinar, Sakir Ongun, Ahmet Cihan, Turan Ozdemir, Dogu Tasdemir, Oktay Ucer, Aegean Study Group of the Society of Urological Surgery
Dokuz Eylul University School of Medicine, Department of Urology, Izmir., Izmir Metropolitan Municipality Esrefpasa Hospital, Department of Urology, Izmir., Ege University School of Medicine, Department of Urology, Izmir., Celal Bayar University School of Medicine, Department of Urology, Manisa., Manisa City Hospital, Department of Urology, Manisa., Bulent Ecevit University School of Medicine, Department of Urology, Zonguldak., Balikesir University School of Medicine, Department of Urology, Balikesir., Nigde Omer Halisdemir University School of Medicine, Department of Urology, Nigde., Turan Ozdemir Ege University School of Medicine, Department of Urology, Izmir.