To clarify Japanese real-world clinical data on the use of desmopressin 25 and 50 μg orally disintegrating tablets (ODT) for male patients with nocturia and evaluate the predictive factors to improve nighttime frequency.
We retrospectively accumulated real-world clinical data from 27 institutions in Japan. Male patients with two or more episodes of nocturia who received desmopressin ODT for nocturnal polyuria (NP) from 2019 through 2021 were included. The primary endpoint was the change of nighttime frequency until 3 months after desmopressin administration. The secondary endpoints were to clarify the persistence rate, adverse events, and predictive factors of decreasing nighttime frequency.
A total of 118 patients were eligible to participate in this study. The persistence rate of desmopressin on the Kaplan-Meier curve at week 12 was 51.3. The reason for discontinuation was mainly the occurrence of adverse events in 67 patients (56.8%), particularly hyponatremia in 7 patients (5.9%). Nighttime frequencies at baseline, - 1 month and 1 - 3 months after desmopressin administration were 4.1 ± 1.3, 2.9 ± 1.4 (P < .01), and 2.6 ± 1.3 (P < .01), respectively. The mean nighttime urine volume voided at baseline was significantly larger in patients whose nighttime frequency decreased by two or more times than in those with a decrease of less than two times.
Desmopressin 25 and 50 μg ODT treatments are feasible for male patients with NP in Japanese real-world clinical practice. Patients with higher voided volumes, particularly in the nighttime, may have great benefit from desmopressin.
Lower urinary tract symptoms. 2022 Aug 05 [Epub]
Yuki Kyoda, Makoto Kimura, Takashi Shimizu, Noriomi Miyao, Takuto Ogasawara, Toshiaki Shimizu, Akihiko Iwasawa, Wakako Yorozuya, Jiro Hashimoto, Koji Ichihara, Fumiyasu Takei, Kosuke Uchida, Nodoka Kouzen, Noriyoshi Suzuki, Kimihito Tachikawa, Akihiko Shibuya, Ippei Muranaka, Manabu Okada, Manabu Igarashi, Kosuke Shibamori, Seisuke Nofuji, Keiko Fujino, Tomohiro Toyota, Yu Ito, Nobuo Shinkai, Kohei Hashimoto, Ko Kobayashi, Toshiaki Tanaka, Naoya Masumori
Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan., Fukuzumi Urological Clinic, Sapporo, Japan., Saka Urological Hospital, Sapporo, Japan., Miyao Urological Clinic, Muroran, Japan., Department of Urology, Steel Memorial Muroran Hospital, Muroran, Japan., Kamui Yawaragi Urological Clinic, Asahikawa, Japan., Iwasawa Clinic, Sapporo, Japan., Department of Urology, Kushiro Red Cross Hospital, Kushiro, Japan., Teine Urological Clinic, Sapporo, Japan., Department of Urology, Sapporo Central Hospital, Sapporo, Japan., Tokachi Urological Clinic, Otofuke, Japan., Sanjukai Hospital, Sapporo, Japan., Department of Urology, JCHO Hokkaido Medical Center, Sapporo, Japan., Nijuuyonken Urological Clinic, Sapporo, Japan., Hakodate Goryoukaku Hospital, Hakodate, Japan., Kaguraoka Urological Clinic, Asahikawa, Japan., Department of Urology, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Japan., Sorachi Kidney and Urological Clinic, Takikawa, Japan.