The aims of this study were to determine the prevalence and predictors of nocturnal polyuria (NP) in Japanese patients. This multicentral, observational study enrolled patients with the chief complaint of nocturia at 17 Japanese institutions between January 2018 and December 2022. The frequency of daily voiding and volume of urination were evaluated using bladder diaries. NP was diagnosed in patients with an NP index of > 33%. The primary endpoint was NP prevalence in patients with nocturia. The secondary endpoints were the prevalence of NP according to sex and age and the identification of factors predicting NP. This study analyzed 875 eligible patients. NP was present in 590 (67.4%) patients, with prevalence rates of 66.6% and 70.0% in men and women, respectively. Age ≥ 78 years, body mass index (BMI) < 23.0 kg/m2, and patients with ischemic heart or cerebrovascular disease were significant predictors of NP (P < 0.001, P < 0.001, P = 0.014, P = 0.016, respectively). This is the first large multicenter study to investigate the prevalence of NP in Japanese patients with nocturia. NP has a prevalence of 67.4%. Significant predictors of NP include age, BMI, and cardiovascular disease.
Scientific reports. 2023 Oct 24*** epublish ***
Koji Iinuma, Yoshinori Nishino, Kanako Matsuoka, Tatsuya Ihara, Shunta Makabe, Ryo Tanji, Yuki Harigane, Kenichiro Ishida, Masayoshi Tamaki, Shigeaki Yokoi, Hiroki Hoshino, Kazuya Yuhara, Toru Yamada, Yasuaki Kubota, Kousei Miwa, Mina Kikuchi, Yoshiyuki Kojima, Takahiko Mitsui, Takuya Koie
Department of Urology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan., Nishino Clinic, 1-55-2 Mitsuicho, Kagamihara, Gifu, 504-0941, Japan., Department of Urology, Fukushima Medical University, 1 Hikariga-Oka, Fukushima, Fukushima, 960-1295, Japan., Department of Urology, University of Yamanashi Graduate School of Medical Sciences, 1110 Shimokato, Chuo, Yamanashi, 408-3898, Japan., Department of Urology, Ohara General Hospital, 6-1 Uwamachi, Fukushima, Fukushima, 960-8611, Japan., Department of Urology, Japanese Red Cross Fukushima Hospital, 7-7 Yashimacho, Fukushima, Fukushima, 960-8530, Japan., Department of Urology, Ohta Nishinouchi Hospital, 2-5-20 Nishinouchi, Koriyama, Fukushima, 963-8558, Japan., Department of Urology, Gifu Prefectural General Medical Center, 4-6-1 Noisiki, Gifu, Gifu, 500-8717, Japan., Department of Urology, Gifu Municipal Hospital, 7-1 Kashimacho, Gifu, Gifu, 500-8513, Japan., Department of Urology, Central Japan International Medical Center, 1-1 Kenkonomachi, Minokamo, Gifu, 5058510, Japan., Department of Urology, Ogaki Municipal Hospital, 4-86 Minaminokawacho, Ogaki, Gifu, 503-8502, Japan., Department of Urology, Japanese Red Cross Takayama Hospital, 3-11 Tenmancho, Takayama, Gifu, 506-8550, Japan., Department of Urology, Tokai Central Hospital, 4-6-2 Soharahigashijimacho, Kagamihara, Gifu, 504-8601, Japan., Department of Urology, Toyota Memorial Hospital, 1-1 Heiwamachi, Toyota, Aichi, 471-0821, Japan., Department of Urology, Japanese Red Cross Gifu Hospital, 3-36 Iwakuracho, Gifu, Gifu, 502-8511, Japan., Sugo Clinic, 1-10-16 Sugo, Gifu, Gifu, 502-0914, Japan., Department of Urology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan. .