Nocturia is a common symptom of lower urinary tract syndrome (LUTS). In previous studies, a close association between LUTS and colorectal inflammation has been reported. However, evidence regarding the association between nighttime urinary frequency and ulcerative colitis (UC) is limited. Herein, we investigated the association between nighttime urinary frequency and clinical outcomes of UC.
We surveyed 287 Japanese patients with UC. A self-administered questionnaire was used to collect the information on the variables studied. Patients were divided into three groups based on nighttime urinary frequency: (1) no voids, (2) one void, and (3) two or more voids. The assessment of clinical outcomes was based on mucosal healing (MH) and clinical remission (CR). The association between nighttime urinary frequency and prevalence of MH and CR was evaluated using multivariate logistic regression analyses.
The prevalence of one nighttime frequency and two or more nighttime frequency in this cohort was 35.5% and 26.8%, respectively. The percentage of MH and CR was 24.7% and 59.2%, respectively. Two or more nighttime frequency (adjusted odds ratio [OR]: 0.31, 95% confidence interval [CI]: 0.13-0.73) was independently and inversely associated with MH. In nonelderly patients (<70 years) and patients in CR, an association between two or more nighttime frequency and MH remained significant (non-elderly: adjusted OR: 0.27, 95% CI: 0.09-0.72 and only CR: adjusted OR: 0.34, 95% CI: 0.12-0.90).
Nighttime urinary frequency was independently and inversely associated with MH in Japanese patients with UC. Nighttime urinary frequency may serve as a complementary physical sign of MH in patients with UC.
Neurourology and urodynamics. 2024 Aug 22 [Epub ahead of print]
Shogo Kitahata, Shinya Furukawa, Teruki Miyake, Osamu Yoshida, Kana Shiraishi, Yu Hashimoto, Kazuhiro Tange, Yagi Sen, Masakazu Hanayama, Tomoyuki Ninomiya, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Department of Gastroenterology, Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan., Health Services Center, Ehime University, Matsuyama, Ehime, Japan., Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Department of Inflammatory Bowel Diseases and Therapeutics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan., Department of Internal Medicine, Saiseikai Imabari Hospital, Imabari, Ehime, Japan., Department of Gastroenterology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan., Department of Gastroenterology, Sumitomo Besshi Hospital, Niihama, Japan., Department of Gastroenterology, Ehime Prefectural Niihama Hospital, Niihama, Ehime, Japan., Department of Internal Medicine, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan., OHASHI Clinic Participate in Gastro-Enterology and Ano-Proctology, Niihama, Ehime, Japan., Endoscopy Center, Ehime University Hospital, Toon, Ehime, Japan.