Division of Urology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.
To evaluate the statistical and clinical efficacy of the pharmacological treatments of nocturia using non-antidiuretic agents.
A literature review of treatments of nocturia specifically addressing the impact of alpha blockers, 5-alpha reductase inhibitors (5ARI) and antimuscarinics on reduction in nocturnal voids.
Despite commonly reported statistically significant results, nocturia has shown a poor clinical response to traditional therapies for benign prostatic hyperplasia including alpha blockers and 5ARI. Similarly, nocturia has shown a poor clinical response to traditional therapies for overactive bladder including antimuscarinics.
Statistical success has been achieved in some groups with a variety of alpha blockers and antimuscarinic agents, but the clinical significance of these changes is doubtful. It is likely that other types of therapy will need to be employed in order to achieve a clinically significant reduction in nocturia.
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Smith AL, Wein AJ. Are you the author?
Reference: BJU Int. 2011 May;107(10):1550-4.
doi: 10.1111/j.1464-410X.2010.09972.x
PubMed Abstract
PMID: 21518417
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