PURPOSE: To determine the relationship between nocturia and nocturnal polyuria (NP).
MATERIALS AND METHODS: The Pubmed and Embase databases were searched for studies, written in English, German, French or Dutch, with original data on adult participants, that investigate the relationship between nocturia and NP. A meta-analysis of the difference in mean nocturnal voiding frequencies between patients with and without NP was conducted. Next, NP risk was compared between participants with and without nocturia. The resulting odds ratio (OR) was subsequently converted to relative risk (RR) with 95% confidence interval (CI).
RESULTS: From 511 references identified, we selected 78 publications of 66 studies,15 of which met the inclusion criteria of this study. Quality scores of studies were generally high for internal validity, but low for external validity. In 7 studies (1,416 participants), we estimated a standardized mean difference of 0.59 (95%CI 0.29-0.89) for nocturnal voidings between NP and non-NP participants. In 8 other studies (with 2,320 participants) we calculated a pooled OR of 4.99 (3.92-6.37) for NP in individuals with nocturia; the corresponding RR, based on a NP risk in the pooled population of 63.8%, was 1.41 (1.37-1.44).
CONCLUSIONS: The association between nocturia and NP is apparent and robust. The clinical importance of the association, however, appears to be less obvious than previously suggested based on single studies. The observed high prevalence of NP, as a result of the applied ICS definition, may be responsible for this discrepancy.
Written by:
Hofmeester I, Kollen BJ, Steffens MG, Bosch JL, Drake MJ, Weiss JP, Blanker MH. Are you the author?
Department of urology, Isala clinics, Zwolle, The Netherlands.
Reference: J Urol. 2013 Oct 29. pii: S0022-5347(13)05839-4.
doi: 10.1016/j.juro.2013.10.100
PubMed Abstract
PMID: 24184367
