PURPOSE: To determine the fluctuation of nocturia over a 12 month period among men with lower urinary tract symptoms (LUTS).
MATERIALS AND METHODS: Men with LUTS allocated to the placebo arm of the U.S. Department of Veterans Affairs Cooperative Studies Program Benign Prostatic Hyperplasia Study. Reported nocturia frequency using the American Urological Association Symptom Index was collected at six time points (2 weeks, 4 weeks, 13 weeks, 26 weeks, 39 weeks, and 52 weeks). Repeated measurement of nocturia over a 1-year period was analyzed using a generalized mixed linear model.
RESULTS: Of the 305 men allocated to the placebo group, 256 participants (84%) gave answers for all six time points. For the entire sample, the mean nocturia count did not significantly vary from baseline (week 2) after adjusting for covariates (p=0.542). However, there was considerable fluctuation in nocturia over 1 year. Of the 93 men with 3 or 4 episodes at baseline, approximately half (47%) had improvement and relatively few (12%) had worsening at 1 year. For the 184 men reporting ≥ 2 episodes of nocturia at baseline, 15% reported 0-1 episodes at 52 weeks. Depending on the case definition during follow-up, the probability of nocturia progression varied between 8% and 54% and nocturia regression varied between 2% and 33%.
CONCLUSIONS: Using repeated questionnaire-based assessments, we observed considerable fluctuation in nocturia; however, overall there was no significant increase in prevalence within a one-year period. These findings may be reassuring to providers and patients who opt to delay interventions for nocturia.
Written by:
Vaughan CP, Johnson TM, Haukka J, Cartwright R, Howard ME, Jones KM, Markland AD, Goode PS, Burgio KL, Tikkinen KA. Are you the author?
Department of Veterans Affairs Birmingham/Atlanta Geriatric Research, Education, and Clinical Center, Birmingham, AL and Atlanta, GA, USA; Division of General Medicine & Geriatrics, Emory University School of Medicine, Atlanta, GA, USA; Department of Veterans Affairs Birmingham/Atlanta Geriatric Research, Education, and Clinical Center, Birmingham, AL and Atlanta, GA, USA; Division of General Medicine & Geriatrics, Emory University School of Medicine, Atlanta, GA, USA; Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland; Department of Epidemiology and Biostatistics, Imperial College London, London, UK; Department of Urogynaecology, St Mary's Hospital, London, UK; The Southeast Permanente Medical Group, Atlanta, GA; Dept of Veterans Affairs, Cooperative Studies Program Coordinating Center, Perry Point, MD; Department of Veterans Affairs Birmingham/Atlanta Geriatric Research, Education, and Clinical Center, Birmingham, AL and Atlanta, GA, USA; Division of Gerontology, Geriatrics, and Palliative Medicine, University of Alabama at Birmingham, Birmingham, AL; Department of Urology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
Reference: J Urol. 2013 Dec 9. pii: S0022-5347(13)06080-1.
doi: 10.1016/j.juro.2013.11.105
PubMed Abstract
PMID: 24333108
