To investigate improvement in nocturia and nocturnal polyuria in nocturnal polyuria patients after silodosin administration by using a 3-day frequency volume chart.
This was a prospective multicenter study.
We enrolled nocturnal polyuria patients (nocturnal polyuria index [NPi]>0. 33), aged ≥60 years, diagnosed with the 3-day frequency volume charts of patients with benign prostatic hyperplasia taking α-blockers. Of the 54 patients, 30 (55. 6%) completed the study according to the study protocol (per-protocol group), and 24 dropped out (dropout group).
Of the 24 patients in the dropout group, 5 withdrew consent due to side effects or lack of efficacy, 7 were lost to follow-up at 4 weeks, 8 were lost to follow-up at 12 weeks, and 4 dropped out due to failure to complete 3-day frequency volume charts at 12 weeks. In the per-protocol group, there was significant improvement in the International Prostate Symptom Score (IPSS), especially question numbers 1, 3, 4, 5, 6, 7, and the quality of life question (P=0. 001, P=0. 007, P<0. 001, P=0. 003, P=0. 049, P<0. 001, and P<0. 001, respectively). The Leeds sleep evaluation questionnaire (LSEQ) score for the sleep question improved from 64. 36 to 70. 43 (P=0. 039). The NPi reduced from 0. 4005 to 0. 3573 (P=0. 027); however, in many cases, there was no improvement in nocturnal polyuria itself. In intention-to-treat analysis, there were significant improvements in IPSS and LSEQ in 45 patients.
In elderly nocturnal polyuria patients, silodosin monotherapy exhibits good efficacy in improving nocturia and nocturnal polyuria; however, the mean NPi was still >0. 33. Considering the high dropout rate of our study due to no implementation of 3-day frequency volume charts, prospective and large-scale studies are needed to confirm our results.
International neurourology journal. 2015 Sep 22 [Epub]
Young Won Kim, Jinsung Park, Hong Chung, Hong-Wook Kim, Hyung Joon Kim, Jae Hung Jung, Won Tae Kim
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea. , Department of Urology, Eulji University School of Medicine, Daejeon, Korea. , Department of Urology, Konkuk University School of Medicine, Chungju, Korea. , Department of Urology, Konyang University College of Medicine, Daejeon, Korea. , Department of Urology, Konyang University College of Medicine, Daejeon, Korea. , Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea. , Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.