The aim of this study is to describe the Nocturia with or without leakage in a population of multiple sclerosis (MS) patients.
This is a retrospective, monocentric study of 309 MS patients, followed up in an experienced neuro-urology centre between 2011 and 2013. All of the patients had daytime urinary symptoms associated with this disorder. Among the patients with N, 2 groups were defined: patients with isolated nocturia (IN), but without nocturnal urinary incontinence (NUI) (group 1); patients with Nocturia, associated with NUI (group 2). The control group (CG) was formed by those patients having no Nocturia. The clinical variables and urodynamics data studied were: sex, age, Expanded Disability Status Scale (EDSS), overactive bladder (OAB) score of the urinary symptoms profile (USP) questionnaire, bladder capacity, detrusor activity and volume at the first detrusor contraction.
53.3% of our patients had Nocturia. Among these, 35.7% had NUI (group 2). The average USP OAB score was statistically greater in patients with Nocturia (9.14 ± 4.3) than in the CG [(5.1 ± 3.5) (p=8.21 E-17)]. The maximum cystomanometric capacity was statistically higher in the CG than in Nocturia patients [(380.17 ± 113.79); (313 ± 128.4), (p= 5.60.E-6)], and a similar outcome was found for the first contraction [(232.58 ± 146.05); (181.14 ± 100.11) (p=0.041)].
IN or NUI are a very frequent problem encountered in MS. Our results suggest that an overactive detrusor is the main mechanism. Further studies are needed to verify the complications arising from Nocturia.
The Journal of urology. 2016 Nov 02 [Epub ahead of print]
E Mauruc, A Guinet-Lacoste, L Falcou, P Manceau, D Verollet, F Le Breton, G Amarenco
Service de Neuro-Urologie et Explorations Périnéales, Hôpital Tenon, APHP, 4 rue de la Chine 75020 Paris, France; GRC 01, UPMC, GREEN: Group of clinical REsEarch in Neurourology, Université Pierre et Marie Curie.