Overactive bladder is a disruptive urinary condition composed of urgency, frequency, and nocturia, which affects a large proportion of men and women. Symptoms are often associated with a decreased quality of life. After optimizing behavioral strategies, pharmacologic intervention is the next consideration for treatment. Therapeutic agents consist primarily of antimuscarinic and β-agonist medications, as well as off-label use of antidepressants in some cases. These medications, although effective, can be associated with considerable adverse side effects. Combination therapies along with novel therapeutics and drug targets are under investigation.
The Urologic clinics of North America. 2022 May [Epub]
Justin Loloi, Whitney Clearwater, Alison Schulz, Sylvia O Suadicani, Nitya Abraham
Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, 1250 Waters Place, Tower 1 PH, Bronx, NY 10461, USA., Department of Obstetrics and Gynecology and Women's Health, Female Pelvic Medicine and Reconstructive Surgery, Montefiore Medical Center, 1250 Waters Place, Tower 2, 9th floor, Bronx, NY 10461, USA., Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA., Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, 1250 Waters Place, Tower 1 PH, Bronx, NY 10461, USA; Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA., Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, 1250 Waters Place, Tower 1 PH, Bronx, NY 10461, USA. Electronic address: .