Overactive bladder (OAB) in children is clinically common and seriously affects the physical and mental health of children. The voiding frequency (VF) is an important basis for the diagnosis of OAB. The emergence of home-uroflowmetry (HUF) has allowed the patients to record the VF while recording the uroflowmetry at home, and the voiding at home can show the real voiding situation. However, the use of HUF to assess OAB in children and its clinical significance has not been reported in the literature. Thus, this study investigate the value of HUF in evaluation of voiding function in children with OAB and survey the VF of healthy children in Mainland China.
From May 2021 to July 2023, 52 children with OAB aged 7-10 years, 48 age-matched volunteers (control group) accepted HUF. Daytime VF and nighttime VF, voided volume (VV) per time, 24-h voided volume (24h-VV), maximum flow rate (Qmax), voiding time (VT), and uroflow pattern were recorded and compute corrected maximum urine flow rate (cQmax). VF in 600 health pupils (7-10 years) from five primary schools in Henan Province China were selected for questionnaire survey by cross-sectional survey and multi-stage sampling methods.
52 children with OAB and 48 healthy children completed the available 48-h HUF recordings. 24-hour, daytime, and nighttime VF, and cQmax were higher in the OAB group than in the control group (P < 0.05). However, average VV, Qmax, and VT were lower in the OAB group than in the control group (P < 0.05). There was no significant difference in 24h-VV between two groups (P > 0.05). A total of 502 questionnaires qualified for statistical analysis, and the 24h-VF was 6.3 ± 0.95 times, daytime VF was 5.6 ± 0.89 times, and nighttime VF was 0.7 ± 0.59 times. There was no significant difference in the comparison of 24-h, daytime, and nighttime VF between boys and girls and in the comparison of VF by age (P > 0.05). Compared with the results of the questionnaire, the difference of VF in HUF control group was not statistically significant (P > 0.05).
The VF in children is similar to that of adults and the HUF is a useful tool with the ability to more realistically record changes in voiding function in children with OAB.
Journal of pediatric urology. 2024 Jul 16 [Epub ahead of print]
Shuai Yang, Zhaokai Zhou, Jing Yang, Qingsong Pu, Yibo Wen, Xingchen Liu, Yanping Zhang, Lei Lv, Jinhua Hu, Israel Franco, Konstantinos Kamperis, Søren Rittig, Qingwei Wang, Jian Guo Wen
Paediatric Urodynamic Centre and Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, China; Henan Joint International Paediatric Urodynamic Laboratory, Henan 450052, China., The First Affiliated Hospital of Zhengzhou University Surgical Reception Centre, Henan 450052, China., Henan Joint International Paediatric Urodynamic Laboratory, Henan 450052, China., Henan Joint International Paediatric Urodynamic Laboratory, Henan 450052, China; Department of Gynecology, Xinyang Central Hospital, Xinyang 464000, Henan, China., Guangzhou Women and Children's Medical Center, Guangzhou 510000, China., Department of Urology, Section of Pediatric Urology, Yale University, New Haven, CT 06520 USA., Department of Paediatrics and Adolescent Health, Aarhus University Hospital, Palle Juul-Jensens Blvd. 99, 8200 Aarhus, Denmark., Paediatric Urodynamic Centre and Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, China; Henan Joint International Paediatric Urodynamic Laboratory, Henan 450052, China. Electronic address: .