Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
One of the factors influencing the treatment compliance of patients with overactive bladder (OAB) symptoms is thought to be the time to reach clinical effectiveness after administering drugs. We investigated the immediate effect of imidafenacin on OAB symptoms.
Imidafenacin (0.1 mg) was administered. OAB symptom scores (OABSS) were evaluated before administration, and at 2 and 4 weeks after administration. The subjective efficacy in patients was examined by recording daily changes for 2 weeks.
Twenty patients were evaluated for efficacy using OABSS and uroflowmetry with postvoid residual volume. Nineteen patients completely recorded daily changes in subjective efficacy. The mean total OABSS decreased gradually during 2 weeks after administration. Patients reported the drug's efficacy to begin 3 days after the commencement of administration. Urinary flow and postvoid residual volume did not change after administration.
The subjective efficacy of imidafenacin was observed from 3 days after the commencement of administration.
Written by:
Kitagawa Y, Kuribayashi M, Narimoto K, Kawaguchi S, Yaegashi H, Namiki M.
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Reference: Urol Int. 2011 Feb 16. Epub ahead of print.
doi: 10.1159/000323843
PubMed Abstract
PMID: 21325789
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