OBJECTIVE:Overactive bladder is a common disease for which current pharmaceutical therapy is often unsatisfactory.
Newer modalities, including Botox and InterStim, can be used when antimuscarinics fail. We compare InterStim and Botox using decision analysis.
METHODS: A Markov state transition decision analysis model was constructed using values for efficacy and complications from the literature. Overall utility was compared monthly. Multiple 1-way sensitivity analyses were performed.
RESULTS: For every month during the simulation, overall utility was higher for Botox than InterStim. After 54 months, cumulative utility was 3.86 versus 3.74, favoring Botox for an average yearly quality-adjusted life-year value of 0.86 versus 0.83. All differences were less than minimally important differences for utilities. Few meaningful thresholds were established supporting the robustness of the model.
CONCLUSIONS: Until appropriately powered randomized controlled trials are available, both InterStim and Botox are reasonable and effective strategies with similar outcomes.
Written by:
Shepherd JP, Lowder JL, Leng WW, Smith KJ. Are you the author?
Division of Urogynecology and Reconstructive Pelvic Surgery, Departments of Obstetrics, Gynecology, and Reproductive Sciences, Urology, and Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.
Reference: Female Pelvic Med Reconstr Surg. 2011 Jul;17(4):199-203.
PubMed Abstract
PMID: 22453853
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