OBJECTIVE: To assess symptoms related to autonomic nervous system alteration in a population of patients suffering from multiple sclerosis (MS) and presenting with urinary symptoms.
PATIENTS AND METHODS: We investigated 65 patients (mean age 47.5 years) suffering from MS, and presenting with urological dysfunction by means of symptom scores, urodynamic investigation, cardiovascular autonomic function tests (orthostatic hypotension testing, Valsalva test, deep breath test, cold pressor test) and sympathetic skin responses.
RESULTS: Forty-five (69%) patients suffered from overactive bladder, 48 (73%) from voiding dysfunction, 14 (21%) from urinary retention and 13 (20%) from fecal incontinence. Urodynamic investigation demonstrated overactive detrusor in 46 (70%) cases, and underactive detrusor in four (6%) cases. Twenty-five (38%) patients had dysautonomia without correlation neither with clinical or urodynamic data, nor gravity of multiple sclerosis (EDSS).
CONCLUSION: In this series, the prevalence of dysautonomia was high in patients suffering from MS and presenting with urinary disorders.
Written by:
Amarenco G, Raibaut P, Hubeaux K, Jousse M, Sheikh Ismaël S, Lapeyre E. Are you the author?
GRC 01 UPMC GREEN groupe de recherche clinique en neuro-urologie, service de neuro-urologie et d'explorations périnéales, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.
Reference: Prog Urol. 2013 Dec;23(17):1505-10.
doi: 10.1016/j.purol.2013.06.010
PubMed Abstract
PMID: 24286553
Article in French.
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