Overactive bladder (OAB) is a common autonomic disorder due mostly to lesions in the micturition-inhibiting area (D1 dopaminergic pathway in the basal ganglia) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Anticholinergic drugs are the mainstay in the treatment of OAB. However, since 1997, anticholinergic adverse events on the cognitive function have been recognized. Drugs with less lipophilic, less permeable through the blood-brain barrier are the choice in the treatment of OAB in elderly neurologic patients.
Written by:
Sakakibara R. Are you the author?
Neurology, Sakura Medical Center, Toho University.
Reference: Rinsho Shinkeigaku. 2013;53(11):1389-92.
doi: 10.5692/clinicalneurol.53.1389
PubMed Abstract
PMID: 24292000
UroToday.com Overactive Bladder (OAB) Section
