PURPOSE: To compare the clinical symptoms, urodynamic diagnosis, and urinary NGF levels at baseline and 5 years later in patients with OAB.
MATERIALS AND METHODS: Patients diagnosed with OAB in a tertiary teaching hospital and had urinary NGF tests 5 years previously were identified from chart reviews. Patients were invited to come back for symptom evaluation, urodynamic studies, and a repeat urinary NGF test. Changes in OAB subtype, USS, and urodynamic diagnosis were classified as improved, stable, or worsened. Changes in urinary NGF/Cr levels were compared between baseline and 5 years later according to the changes in bladder conditions.
RESULTS: A total of 75 patients (30 women and 45 men) completed the study. The mean age was 73.5±10.3 years. The urinary NGF/Cr levels showed no significant differences among patients with improved, stationary, or worsened bladder conditions based on the OAB or USS subtypes. However, urinary NGF/Cr levels were significantly decreased in patients with improved urodynamic diagnosis (0.94±1.36 v 0.17±0.19 pg/mg, p= 0.02), significantly increased in patients with worsened urodynamic diagnosis (0.55±0.85 v 2.08±2.81 pg/mg, p= 0.04), and showed no change in those with stable urodynamic diagnosis. Multiple linear regression analysis revealed the change of urodynamic diagnosis was still predictive of change in urinary NGF/Cr levels after adjusting for age, gender, OAB and USS subtypes (p= 0.001).
CONCLUSIONS: Urinary NGF/Cr levels did not reflect the changes of bladder conditions based on subjective symptoms. However, the urinary NGF/Cr levels did reflect the dynamic changes of bladder pathophysiology according to urodynamic findings.
Written by:
Chuang FC, Liu HT, Wang LY, Kuo HC. Are you the author?
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. ; ; ;
Reference: J Urol. 2014 Mar 1. pii: S0022-5347(14)00349-8.
doi: 10.1016/j.juro.2014.02.091
PubMed Abstract
PMID: 24594404
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