Overactive bladder (OAB) is one of the most common bothersome urological diseases.
It also has a negative economic impact. Pathophysiology entails changes in neurogenic and myogenic factors, as well as urinary biomarkers such as nerve growth factor (NGF) and prostaglandins (PGs). With symptoms from OAB-Dry to OAB-Wet, the urodynamic pattern of OAB bladder is often characterized by idiopathic detrusor overactivity with lower threshold of sensation, diminished compliance and capacity. Treatment ranges from a combination of behavioral modifications (BM)/ pelvic floor muscle training (PFMT) to combinations of antimuscarinics, Botox injection, nerve stimulation and augmentation cystoplasty. Herein, a contemporary review on the different aspects of management of refractory OAB in patients without neuropathic disorders is presented.
Written by:
Wadie BS. Are you the author?
Voiding Dysfunction and Female Urology, Urology& Nephrology Center, Mansoura University, Mansoura, Egypt.
Reference: Curr Urol Rep. 2014 Sep;15(9):438.
doi: 10.1007/s11934-014-0438-x
PubMed Abstract
PMID: 25015301
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