It is now clearly recognized that the function of the lower urinary tract represents a complex interaction between the bladder and its outlet, acting under the control of the central nervous system.
While in the past attention has principally focused on the motor (efferent) control of the bladder, sensory (afferent) innervation is now known to be an important therapeutic target. This change in emphasis is strongly supported by both basic science and clinical evidence demonstrating the efficacy of therapy directed at the afferent system. This chapter summarizes the neurophysiological control mechanism that underpins normal lower urinary tract function, emphasizing the importance of the afferent system as a potential therapeutic target.
Written by:
Chapple C. Are you the author?
The Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, United Kingdom.
Reference: Neurourol Urodyn. 2014 Jul;33 Suppl 3:S6-S13.
doi: 10.1002/nau.22635
PubMed Abstract
PMID: 25042142
UroToday.com Overactive Bladder (OAB) Section
