OBJECTIVES: To investigate the characteristics of psychological distress (PD), personality traits, and family support in women with overactive bladder syndrome (OAB), and the effects of antimuscarinic treatment.
STUDY DESIGN: Women with and without OAB (age- and body mass index [BMI]-matched control group) were prospectively enrolled; they recorded bladder diaries, underwent urodynamic studies, and completed PD, personality traits, and filled family support questionnaires before and after antimuscarinic treatment. OAB women underwent treatment with tolterodine or solifenacin for 12 weeks. The control group completed questionnaires.
MAIN OUTCOME MEASURES: The differences in PD, personality traits, and family support scores between both groups, and the changes after antimuscarinic treatment in OAB women.
RESULTS: Eighty-five women with OAB (tolterodine, n=42; solifenacin, n=43) and 65 without OAB completed the studies. Linear regression analysis with age and BMI adjustment revealed: coefficients of OAB were significant (all P< 0.05) for somatic complaints (mean: 0.87 vs. 0.63, coefficient=0.21), obsessive-compulsive symptoms (0.69 vs. 0.44, coefficient=0.25), anxiety symptoms (0.42 vs. 0.27, coefficient=0.14), General Symptom Index (GSI, 0.48 vs. 0.33, coefficient=0.14), neuroticism (9.23 vs. 5.17, coefficient=3.73), and extroversion-introversion (13.64 vs. 15.25, coefficient=-1.73). Anxiety symptoms (0.42 vs. 0.36) and GSI (0.48 vs. 0.39) improved after antimuscarinics (all P< 0.05). High Overactive Bladder Symptom Score questionnaire score (coefficient=-0.39), low hostility score (coefficient=2.11), and high additional symptoms score (coefficient=-1.46) were associated with good therapeutic effect (all P< 0.05).
CONCLUSIONS: OAB women experience more PD, neuroticism, and introversion than asymptomatic women, and antimuscarinics could improve PD.
Written by:
Hsiao SM, Liao SC, Chen CH, Chang TC, Lin HH. Are you the author?
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan; Department of Psychiatry, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Reference: Maturitas. 2014 Sep 3. pii: S0378-5122(14)00270-9.
doi: 10.1016/j.maturitas.2014.08.009
PubMed Abstract
PMID: 25238744