Can we predict which patients will present resolution of detrusor overactivity (DO) after transurethral resection of the prostate (TURP)? - Abstract

PURPOSE: The aim of the present study is to determine which clinical and urodynamic variables may be related to the persistence of DO after transurethral resection of the prostate.

MATERIAL AND METHODS: Analysis of 46 patients with BOO due to BPH who underwent TURP from 2011 to 2012. All patients underwent urodynamic analysis pre and post operatively after 12 months. The clinical and urodynamic variables in the preoperative were correlated with the resolution of DO in the postoperative period.

RESULTS: Patients with DO in the preoperative period were older (65.2 vs 61.1 years; p = 0.041), had higher IPSS score (25.2 vs 19; p = 0.014) and higher maximum flow rates (8.6 vs 6.6 ml/s; p = 0.039). Patients who persisted with DO were statistically older than those with resolution (69 vs 63 years; p = 0.043 ng/ml). Among patients with a MCC under 250 ml, 63.6% persisted with DO against only 20% among those with a MCC over 250 ml (p = 0.024). Analyzing urodynamic variables together, we found that patients presenting a MCC < 250 ml and a amplitude of DO over 40 cmH2O resulted in a 66.7% chance of persistence of DO (p = 0.041). When the patient has these characteristics associated with an early DO, the chance of persistence of DO reached 83.3% (p = 0.013).

CONCLUSIONS: Advanced patient age together with a low MCC and an early and high amplitude of DO are the most important predictors for persistence of DO after relief of BOO.

Written by:
Antunes AA, Iscaife A, Reis ST, Albertini A, Nunes MA, Lucon AM, Nahas WC, Srougi M.   Are you the author?
Division of Urology - University of Sao Paulo Medical School.

Reference: J Urol. 2015 Jan 9. pii: S0022-5347(15)00004-X.
doi: 10.1016/j.juro.2014.12.095


PubMed Abstract
PMID: 25583645

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