SCOTTSDALE, AZ USA (UroToday.com) - This was a retrospective pilot study to compare efficacy in 50 patients with urgency UI who received only BOTOX® injections (n=25) compared to those who received both InterStim® therapy and BOTOX® injections (n=25).
In the BOTOX®-only group there was an overall reduction in UI episodes of 58% compared to 68% in the group with combined BOTOX® and InterStim®. The authors presented urodynamic parameters of cystometric bladder capacity that indicated that the combination groups had slightly higher capacity than BTA-alone group (303 ml, 215 ml respectively). Flow rate was the same.
The conclusion was that the combined group had a 10% higher reduction in UI than patients treated with BTA alone. But all reported outcomes were not statistically significant, so the authors conclusions that “possible bladder neuro-stimulatory changes induced by InterStim® could influence susceptibility to treatment with BTA” is not supported.
Presented by G. Kirkpatrick, G. Brown, and D. Sussman at the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction (SUFU) Winter Meeting - February 24 - 28, 2015 - JW Marriott Camelback Inn Resort & Spa - Scottsdale, AZ USA
Reported for UroToday by Diane K. Newman, DNP, FAAN, BCB-PMD, medical writer for UroToday.com.