Mirabegron, the first β3-adrenoceptor agonist in clinical practice, is approved for treatment of overactive bladder (OAB) syndrome symptoms. Because β3-adrenoceptors are expressed in cardiovascular (CV) tissues, there are concerns that OAB treatment with β3-adrenoceptor agonists may affect the heart and vasculature.
To provide a summary of CV effects of β3-adrenoceptor agonists in clinical studies.
A systematic literature search from inception until November 2014 was performed on studies in PubMed and Medline.
Twenty papers, published between 1994 and 2014, were identified: mirabegron (16), solabegron (2), AK-677 (1), and BRL35135 (1). More detailed CV data from mirabegron studies were available in online regulatory documents filed with the US Food and Drug Administration and the UK National Institute for Health and Care Excellence.
The CV safety of mirabegron appears to be acceptable at therapeutic doses and comparable with that of antimuscarinic agents, currently first-line therapy for OAB.
In this review we looked at the cardiovascular (CV) effects of β3-adrenoceptor agonists used for the treatment of overactive bladder (OAB). The CV safety of mirabegron (the only clinically approved β3-adrenoceptor agonist) appears to be acceptable at therapeutic doses and comparable with that of antimuscarinic agents, the current first-line therapy for OAB.
European urology. 2015 Sep 25 [Epub ahead of print]
Gian Marco Rosa, Simone Ferrero, Victor W Nitti, Adrian Wagg, Tahir Saleem, Christopher R Chapple
IRCCS AOU San Martino - University of Genoa, Genoa, Italy. , IRCCS AOU San Martino - University of Genoa, Genoa, Italy. , Department of Urology, NYU Langone Medical Center, New York, NY, USA. , Division of Geriatric Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. , Astellas Pharma Europe Ltd, Chertsey, Surrey, UK. , Department of Urology, Royal Hallamshire Hospital, Sheffield, UK.