Comparing patient-reported functional outcomes after radical prostatectomy in historical and contemporary practice.

Modifications to surgical technique, particularly the widespread adoption of robotic surgery, have been proposed to improve functional recovery after prostate cancer surgery. However, rigorous comparison of men in historical versus contemporary practice to evaluate the cumulative effect of these changes on urinary and sexual function after radical prostatectomy is lacking.

We compared prospectively collected patient-reported urinary and sexual function from historical (PROSTQA, n=235) and contemporary (MUSIC-PRO, n=1215) cohorts at the University of Michigan to understand whether modern techniques have resulted in functional improvements for men undergoing prostate cancer surgery.

We found significant differences in baseline function, with better urinary (median [IQR]; 100 [93.8-100] vs 93.8 [85.5-100], p<0.001) and sexual scores (median [IQR]; 83.3 [66.7-100] vs 74.4 [44.2-87.5], p<0.001) prior to treatment in PROSTQA compared to MUSIC-PRO patients, respectively. There was no statistically significant difference in the pattern of urinary incontinence recovery after surgery from 6-24 months between groups (p=0.14). However, men in the contemporary MUSIC-PRO group did have significantly better recovery of sexual function compared to men in the historical PROSTQA group (p<0.0001). Further, we found that contemporary practice consists of men with more unfavorable demographic and clinical characteristics compared to historical practice.

Our results demonstrate that the widespread alterations in prostate cancer surgery over the past two decades have yielded improvements in sexual, but not urinary, function recovery.

The Journal of urology. 2023 Aug 11 [Epub ahead of print]

Udit Singhal, Brent K Hollenbeck, Samuel D Kaffenberger, Simpa S Salami, Arvin K George, Ted A Skolarus, Jeffrey S Montgomery, Daniela A Wittmann, David C Miller, John T Wei, Ganesh S Palapattu, James E Montie, Rodney L Dunn, Todd M Morgan

Department of Urology, Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109.