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Decision regret and long-term success rates after ventral buccal mucosa graft urethroplasty

Objectives: To characterise the long-term success rate of ventral onlay buccal mucosa graft urethroplasty (vBMG) in the management of bulbar urethral stricture disease (USD), assess patient-reported postoperative satisfaction and decision regret, and delineate clinical factors impacting patient-reported metrics.

Subjects and Methods: Patients with prior vBMG for bulbar USD, performed at Cleveland Clinic between 2003 and 2022, were contacted and brief structured interviews were performed. Stricture recurrence and need for secondary procedures, baseline demographics, and patient-reported outcome surveys were collected. The surveys included the Decision Regret Scale (DRS), the Urethral Stricture Symptom Impact Measure (USSIM) and the 10-item Patient-Reported Outcomes Measurement Information System Short Form, version 1.2 (PROMIS-10). Descriptive, univariate and multivariable analyses were performed for clinical outcomes and survey responses.

Results: A total of 104 patients recorded responses. The median patient age was 49 years and the median follow-up was 7.4 years at time of survey. The median graft length was 5 cm and 38% of patients underwent partial thickness augmented anastomotic urethroplasty. At time of follow-up, 10 patients underwent a secondary procedure. Moderate to severe regret on the DRS was found in 12% of patients, and greater regret was associated with recurrence. The mean physical and mental health PROMIS-10 Global Health T-scores were 52 and 53. The mean total USSIM score was 56. A significant correlation was found between USSIM and DRS scores, with higher DRS score and recurrence negatively impacting USSIM score. USSIM scoring across all domains was significantly worse in the moderate to severe DRS group.

Conclusion: This study showed that vBMG for bulbar USD confers both high success rates and patient-reported satisfaction at extended follow-up, based on emerging and validated patient-reported outcome measures.

Javier E. Santiago,1 Michael D. Gross,1 João Pedro Accioly,1 Bryan B. Voelzke,2 Benjamin N. Breyer,3 Roger K. Khouri,4 Molly E. DeWitt-Foy,1 Kenneth W. Angermeier,1 Hadley M. Wood1

  1. Cleveland Clinic Foundation, Glickman Urological & Kidney Institute, Cleveland, Ohio, USA
  2. Spokane Urology, Spokane, Washington, USA
  3. Department of Urology, University of California San Francisco, San Francisco, California, USA
  4. Smith Institute for Urology at Northwell Health, Reconstructive Urology & Men's Health, North New Hyde Park, New York, USA
Source: Santiago, J.E., Gross, M.D., Accioly, J.P., Voelzke, B.B., Breyer, B.N., Khouri, R.K., DeWitt-Foy, M.E., Angermeier, K.W. and Wood, H.M. (2024), Decision regret and long-term success rates after ventral buccal mucosa graft urethroplasty. BJU Int. https://doi.org/10.1111/bju.16566.