Medway NHS Foundation Trust, Windmill Road, Gillingham, Kent, UK, ME7 5NY.
The aim of the study was to determine whether a 6-week course of 5 mg of solifenacin succinate used to treat mixed incontinence, produces measurable changes in the appearance of the urethral sphincter.
Twenty-six women undergoing treatment for mixed incontinence were recruited from a urogynaecology unit after failing to improve with conservative treatments and bladder drill. All underwent dual channel subtracted cystometry, which showed mixed urodynamic stress incontinence and detrusor overactivity. All patients underwent a 3D transperineal ultrasound before solifenacin therapy was started and after 6 weeks of treatment. The urethral length, width and volume of the smooth muscle and total sphincter volume were compared before and after the treatment.
Clinically, 13 reported no improvement in either stress or urge incontinence. Eight women reported improvement in their urgency symptoms but no benefit in their stress leakage. Four women reported resolution of both stress and urge incontinence. One woman reported worsening of her bladder symptoms. There was no significant change in the urethral length (p = 0.27), width (p = 0.50), volume of smooth muscle (p = 0.87) or total sphincter volume (p = 0.60) before and after treatment with solifenacin.
A 6-week course of solifenacin resulted in no measurable changes in the appearance of the urethral sphincter.
Written by:
Duckett J, Basu M. Are you the author?
Reference: Int Urogynecol J Pelvic Floor Dysfunct. 2011 Apr 6. Epub ahead of print.
doi: 10.1007/s00192-011-1410-7
PubMed Abstract
PMID: 21468740
UroToday.com Urinary Incontinence (UI) Section
