GOAL: The aim was to review the literature on estrogens and lower urinary tract.
MATERIAL: A review of literature through the PubMed library until December 31, 2012 was carried out using the following keywords: lower urinary tract, bladder, urethra, nervous central system, innervation, female, women, estrogen, estradiol, urogenital atrophy, urinary incontinence, overactive bladder, urinary tract infection.
RESULTS: On the bladder, estrogens are involved in the trophicity, vascularisation, alpha-adrenergic, cholinergic and muscarinic receptor density, detrusor contractility and inflammation. On the urethra, they impact vascularisation, contractility, urethral pulse and tone, anatomical and functional length. On the neurological control, they act on capsaicin-sensitive afferent fibres, neurological regeneration, nerve growth factor expression and viscerovisceral sensitisation.
CONCLUSION: Estrogens play a major role on the lower urinary tract physiology and physiopathology both on the urethra and the bladder.
Written by:
Gamé X, Rischmann P, Arnal JF, Malavaud B. Are you the author?
Département d'urologie, CHU Rangueil, TSA 50032, 31059 Toulouse, France; Institut national de la santé et de la recherche médicale U1048, laboratoire de physiologie, CHU Rangueil, TSA 50032, 31059 Toulouse, France.
Reference: Prog Urol. 2013 Jun;23(8):502-10.
doi: 10.1016/j.purol.2013.03.012
PubMed Abstract
PMID: 23725580
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