Objective: To determine the applicability and long-term outcome of endoscopic injection of dextranomer/hyaluronic acid (Dx/HA) to correct incontinence in patients who had previously undergone continent urinary reconstruction.
Methods: A retrospective cohort study was performed of all patients who underwent Dx/HA injection at our institution from January 2001 to June 2011. All patients had adequate bladder capacity and compliance on maximized medical therapy before injection. "Success" was defined as either "continence" (daytime dry interval > 3 hours) or "improvement" (daytime dry interval > 2 hours).
Results: A total of 22 children (16 females and 6 males) had Dx/HA injections for persistent incontinence from either bladder neck (7), Mitrofanoff (10), or both (5). Median age at injection was 13 years (range, 4 - 21). Children underwent an average of 1.6 injection sessions per patient with an average of 2.6 ml of Dx/HA per session. At a median follow-up of 72 months (range, 4 - 104), 19 patients (86.4%) had successful results (16 continent, 3 improved). For those incontinent from bladder neck, 42% became continent after 1, 75% after 2, and 83% after 3 injections, with a success rate of 91% (10 continent, 1 improved). For those incontinent from Mitrofanoff, 20% became continent after 1, and 73% after 2 injections, with a success rate of 86% (11 continent, 2 improved).
Conclusions: Endoscopic injection of Dx/HA to correct residual incontinence in selected children following urinary reconstruction appears to be safe and effective, achieving a dry interval in over 2/3 of patients.
Written by:
Riachy E, DeFoor WR, Reddy PP, Alam S, Noh PH, Sheldon C, Minevich E. Are you the author?
Cincinnati children's Hospital Medical Center, Pediatric Urology, 3333 Burnet Ave, Cincinnati, Ohio, United States, 45229.
Reference: J Endourol. 2014 Sep 29. Epub ahead of print.
doi: 10.1089/end.2014.0326
PubMed Abstract
PMID: 25265053