Orthotopic neobladder (ONB) and ileal conduit (IC) are the most commonly practiced techniques of urinary diversion (UD) after radical cystectomy (RC) in bladder cancer patients. Data in the literature is still discordant regarding which UD technique offers the best HR-QoL.
The objective was to compare HR-QoL in patients undergoing ONB and IC after RC, through a systematic review of the literature and meta-analysis.
We performed a literature search of PubMed, ScienceDirect, CochraneLibrary, and ClinicalTrials.Gov in September 2017 according to the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. The studies were evaluated according to the "Oxford Center for Evidence-Based Medicine" criteria. The outcome measures evaluated were subdomains' scores of Bladder Cancer Index BCI: urinary function (UF), urinary bother (UB), bowel function (BF), bowel bother (BB), sexual function (SF) and sexual bother (SB). Continuous outcomes were compared using weighted means differences, with 95% confidence intervals. The presence of publication bias was examined by funnel plots.
Four studies met the inclusion criteria. The pooled results demonstrated better UF and UB scores in IC patients: differences were -18.17 (95% CI: -27.49, -8.84, P=0.0001) and -3.72 (95% CI: -6.66, -0.79, P=0.01) respectively. There was no significant difference between IC and ONB patients in terms of BF and BB. SF was significantly better in ONB patients: the difference was 12.7 (95% CI, 6.32, 19.08, P<0.0001). However no significant difference was observed regarding SB.
This meta-analysis of non-randomized studies demonstrated a better HR-QoL in urinary outcomes in IC patients compared with ONB patients.
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2018 Mar 20 [Epub ahead of print]
I Ziouziou, J Irani, J T Wei, T Karmouni, K El Khader, A Koutani, A Iben Attya Andaloussi
Service d'urologie B, faculté de médecine et pharmacie de Rabat, université Mohamed-V, CHU Ibn-Sina, Rabat, Maroc. Electronic address: ., Service d'urologie, CHU de Bicêtre, 78, rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France. Electronic address: ., Department of urology, university of Michigan, Ann Arbor, Michigan, USA. Electronic address: ., Service d'urologie B, faculté de médecine et pharmacie de Rabat, université Mohamed-V, CHU Ibn-Sina, Rabat, Maroc. Electronic address: ., Service d'urologie B, faculté de médecine et pharmacie de Rabat, université Mohamed-V, CHU Ibn-Sina, Rabat, Maroc. Electronic address: ., Service d'urologie B, faculté de médecine et pharmacie de Rabat, université Mohamed-V, CHU Ibn-Sina, Rabat, Maroc. Electronic address: ., Service d'urologie B, faculté de médecine et pharmacie de Rabat, université Mohamed-V, CHU Ibn-Sina, Rabat, Maroc. Electronic address: .
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