The value of the Vesicle Imaging-Reporting and Data System (VI-RADS) in the diagnosis of muscle-invasive bladder cancer (MIBC) for urothelial carcinoma with variant histology (VUC) remains unknown. We retrospectively evaluated 360 consecutive patients with bladder cancer (255 pure urothelial carcinoma [PUC] and 69 VUC) who underwent multiparametric magnetic resonance imaging between 2011 and 2019. VI-RADS scores assigned by four readers were significantly higher for the VUC group than for the PUC group (p < 0.05). In the cohort of 122 pair-matched patients, there was no significant difference in VI-RADS score distribution between the PUC and VUC groups for all readers (p > 0.05). The area under the receiver operating characteristic curve for MIBC diagnosis via overall VI-RADS score was 0.93-0.94 for PUC and 0.89-0.92 for VUC, with no significant difference between the PUC and VUC groups (p = 0.32-0.60). These data suggests that VI-RADS scores achieved high diagnostic performance for detection of muscle invasion in both PUC and VUC. PATIENT SUMMARY: The Vesical Imaging-Reporting and Data System (VI-RADS) is a standardized system for reporting on detection of muscle-invasive bladder cancer via magnetic resonance imaging (MRI) scans. Our study shows that VI-RADS is also highly accurate for diagnosis for different variants of muscle-invasive bladder cancer, with good inter-reader agreement.
European urology oncology. 2022 Aug 03 [Epub ahead of print]
Yuki Arita, Soichiro Yoshida, Keisuke Shigeta, Thomas C Kwee, Hiromi Edo, Naoko Okawara, Masahiro Hashimoto, Ryota Ishii, Ryo Ueda, Shuji Mikami, Motohiro Fujiwara, Yuma Waseda, Eiji Kikuchi, Yasuhisa Fujii, Masahiro Jinzaki
Department of Radiology, Keio University School of Medicine, Tokyo, Japan. Electronic address: ., Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan., Department of Urology, Keio University School of Medicine, Tokyo, Japan., Department of Radiology, Nuclear Medicine, and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands., Department of Radiology, National Defense Medical College, Tokorozawa, Japan., Department of Radiology, Keio University School of Medicine, Tokyo, Japan., Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan., Office of Radiation Technology, Keio University Hospital, Tokyo, Japan., Department of Pathology, Keio University School of Medicine, Tokyo, Japan., Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.