Localized node-positive bladder cancer is characterized by a high degree of heterogeneity, leading to significant variability in overall survival outcomes among affected individuals. The absence of standardized treatment guidelines presents a critical challenge in managing these patients effectively. This comprehensive review article delves into the pathophysiology, clinical significance, and management of node-positive bladder cancer. It critically evaluates the current therapeutic landscape and explores emerging treatment strategies, including novel drugs currently undergoing clinical trials. By synthesizing the latest research findings, the review aims to provide valuable insights into the optimal management of node-positive urothelial cell carcinoma, ultimately contributing to improved patient outcomes and quality of life.
Clinical advances in hematology & oncology : H&O. 2024 Oct [Epub]
Hyma V Polimera, Priyanka Bhatia, Megan Wheelden, Stuthi Perimbeti, Joshua Warrick, Monika Joshi
Department of Medicine, Division of Hematology-Oncology, Penn State Cancer Institute, Hershey, Pennsylvania., Department of Pathology, Penn State Hershey Medical Center, Hershey, Pennsylvania.