Identification of factors associated with upgrading from T1 to muscle invasive disease is critical for better patient selection.
The authors evaluated 90 patients undergoing radical cystectomy for T1 disease. 33% had muscle invasive disease and 7.8% had lymph node metastases. On multivariate analysis the presence of CIS was the only preoperative factor significantly associated with pathologic upstaging at radical cystectomy.
Obviously, without including all patients they evaluated with T1 disease, it is difficult to know if the confounders associated with selecting patients for cystectomy vs. intravesical therapy played a role in altering the prognostic factors associated with pathologic upstaging.
Presented by Gautam Jayram, et al. at the American Urological Association (AUA) Annual Meeting - May 14 - 19, 2011 - Walter E. Washington Convention Center, Washington, DC USA
Reported for UroToday by David P. Wood Jr., MD, Professor, Department of Urology, University of Michigan Health System.
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