After neoadjuvant chemotherapy (NAC), the impact of the timing of cystectomy delivery on these outcomes is unknown. Median time to cystectomy from the first and last day of NAC was 16.6 weeks and 6.9 weeks respectively. In univariate analysis, pathologic stage, LVI and NAC regimen were associated with overall survival. In multivariate analysis, only pathologic stage remained significant. The timing of cystectomy delivery after NAC did not significantly alter overall survival in this cohort. Patient sample size was most robust within 10 weeks of NAC termination.
The authors conclude that performing a cystectomy within 10 weeks of completing NAC is acceptable.
Presented by Ajjai Alva, et al. at the American Urological Association (AUA) Annual Meeting - May 14 - 19, 2011 - Walter E. Washington Convention Center, Washington, DC USA
Reported for UroToday by David P. Wood Jr., MD, Professor, Department of Urology, University of Michigan Health System.
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