Radiology Department, University Campus Bio Medico, Rome, Italy.
Urology Department, Regina Elena National Cancer Institute, Rome, Italy.
Study Type - Diagnostic (exploratory cohort) Level of Evidence 3a.
What's known on the subject? and What does the study add? Preoperative imaging of nodal status in patients undergoing radical cystectomy for bladder cancer lacks diagnostic accuracy. This is the first study that has investigated nodal metastates in bladder cancer using DW-MRI. ADC derived from DW-MRI may be used to differentiate metastatic from non-metastatic lymph nodes.
To evaluate whether DW-MRI improves the detection of pelvic lymph nodes metastates in patients with bladder cancer undergoing radical cystectomy.
36 patients with CT scan negative for nodal metastates underwent DW-MRI before surgery. Diagnostic accuracy of DW-MRI was compared with histopathological findings.
Mean ADC value was 0.85 × 10-3 mm3 /s in the nodal metastatic group and 1 × 10-3 mm3 /s in the nodal non-metastatic group (P = 0.02). The ADC cut-off value, obtained by the ROC curve was 0.86 × 10-3 mm3 /s. Patient-based sensitivity, specificity and positive and negative predictive values were 76.4%, 89.4%, 26.6%, and 71.4%, respectively.
DW-MRI may be used to differentiate metastatic from non-metastatic lymph nodes in patients with high-grade bladder cancer.
Written by:
Papalia R, Simone G, Grasso R, Augelli R, Faiella E, Guaglianone S, Cazzato R, Vescovo RD, Ferriero M, Zobel B, Gallucci M. Are you the author?
Reference: BJU Int. 2011 Aug 25. Epub ahead of print.
doi: 10.1111/j.1464-410X.2011.10446.x
PubMed Abstract
PMID: 21883835
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