Urothelial bladder tumours in childhood are extremely rare, with most cases being low grade, superficial disease of the papillary subtype with favourable outcomes. Urothelial (Clear Cell Variant) Carcinoma of Bladder (UCCVCB) is an exceptional histological finding in both the adult and paediatric population. Herein we describe the first case of UCCVCB diagnosed in childhood. With this case being only the fourth report of confirmed muscle invasion in childhood, we discuss the entity of UCCVCB, and furthermore review all previously reported confirmed cases of childhood muscle invasive urothelial bladder cancer in general.
Urology. 2016 May 17 [Epub ahead of print]
Shaul Yosef Minkowitz, Reubina Wadee, Ahmed Adam
Department of Urology, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa; Department of Urology, Helen Joseph Hospital, Johannesburg, South Africa; Department of Paediatric Urology, Rahima Moosa Mother & Child (Coronation) Hospital, Johannesburg, South Africa; Division of Urology, University of the Witwatersrand, Johannesburg, South Africa.. Electronic address: ., Division of Anatomical Pathology, University of the Witwatersrand and the National Health Laboratory Services (NHLS), Johannesburg, South Africa.. Electronic address: ., Department of Urology, Helen Joseph Hospital, Johannesburg, South Africa; Department of Paediatric Urology, Rahima Moosa Mother & Child (Coronation) Hospital, Johannesburg, South Africa; Division of Urology, University of the Witwatersrand, Johannesburg, South Africa.. Electronic address: .