Methods: MEDLINE, Embase, Pubmed, CINAHL, PEDro, and CENTRAL databases were searched to July 16, 2020.
Results: A total of 17 trials were included incorporating aerobic exercise, resistance exercise, or soccer interventions. Few (n = 4, 0.5%) serious adverse events were attributed to exercise participation, with none related to bone metastases. Mixed efficacy results were found, with exercise eliciting positive changes or no change. The majority of trials included an element of supervised exercise instruction (n = 16, 94%) and were delivered by qualified exercise professionals (n = 13, 76%).
Conclusions: Exercise appears safe and feasible for individuals with bone metastases when it includes an element of supervised exercise instruction.
Sarah Weller,1 Nicolas H. Hart,2-4 Kate A.Bolam,5 Sami Mansfield,6 Daniel Santa Mina,7 Kerri M.Winters Stone,8 Anna Campbell,9 Friederike Rosenberger,10 Joachim Wiskemann,10 Morten Quist,11 Prue Cormie,12 Jennifer Goulart,13 Kristin L.Campbell,14
- Provincial Programs, BC Cancer, 750 West Broadway, Vancouver, BC, V5Z 1H5, Canada
- Cancer and Palliative Care Outcomes Centre, Queensland University of Technology, 191 Ipswich Rd, Woolloongabba, QLD, 4102, Australia
- Exercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia
- Institute for Health Research, University of Notre Dame Australia, 23 High Street, Freemantle, WA, 6160, Australia
- Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Fack 23400, SE-141 83 Huddinge, Stockholm, Sweden
- Cancer Wellness for Life, 8022 Reeder Street, Lenexa, KS, 66214, USA
- Faculty of Kinesiology and Physical Education, University of Toronto, 27 King’s College Cir, Toronto, Ontario, ON M5S, Canada
- Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA
- Department of Sport, Exercise and Health & Science, School of Applied Sciences, Edinburgh Napier University, Sighthill Court, Edinburgh, EH11 4BN, UK
- Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, Heidelberg, 69120, Germany
- The University Hospitals Centre for Health Research, Rigshospitalet, Blegdamsvej 9, 2100, København, Denmark
- Mary MacKillop Institute for Health Research, Australian Catholic University, 5/215 Spring Street, Melbourne, VIC, 3000, Australia
- Department of Radiation Oncology, BC Cancer, 2410 Lee Avenue, Victoria, BC, V8R 6V5, Canada
- Department of Physical Therapy, 212-2177 Wesbrook Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
Source: Weller S., Hart N., Bolam K, et al. "Exercise for Individuals with Bone Metastases: A Systematic Review." Critical Reviews in Oncology/Hematology. 2021. Volume 166, 103433.