Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, United States.
Previous studies have shown that the Ron receptor is overexpressed in prostate cancer and Ron expression increases with disease severity in humans and the mouse TRAMP model. Here, the causal role of Ron overexpression in the murine prostate was examined in the development and progression of prostate cancer. Transgenic mouse strains were generated which selectively overexpressed Ron in the prostate epithelium and prostate histopathology was evaluated and compared to wild type controls. Ron overexpression led to the development of prostate intraepithelial neoplasia (mPIN) with local invasion and was associated with increases in prostate cell proliferation and decreases in cell death.
Written by:
Gray JK, Paluch AM, Stuart WD, Waltz SE. Are you the author?
Reference: Cancer Lett. 2011 Sep 24. Epub ahead of print.
doi: 10.1016/j.canlet.2011.09.021
PubMed Abstract
PMID: 22004727
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