Phenethyl isothiocyanate (PEITC) is a candidate anticancer compound found in certain cruciferous vegetables.
In our tumor cell xenograft model, dietary administration of PEITC (100-150 mg/kg body weight/d) inhibited androgen-responsive LNCaP human prostate cancer cell tumor growth. We found that dietary treatment with PEITC significantly inhibited tumor platelet/endothelial cell adhesion molecule (PECAM-1/CD31) expression, a marker of angiogenesis. By contrast, we did not find the inhibitory effects of PEITC on tumor growth to be associated with alteration of specific markers for apoptosis, cell proliferation or androgen receptor-mediated pathways. Consistent with in vivo results, PEITC exerted little effects on cell proliferation, cell cycle and androgen-dependent pathways. Interestingly, PEITC significantly attenuated LNCaP cell plating efficiency that correlated with inhibition of integrin family proteins integrin β1, α2 and α6 mRNA expression. Thus, PEITC may be a dietary factor that inhibits androgen-responsive prostate tumor growth indirectly by selectively targeting factors involved in the tumor microenvironment.
Written by:
Hudson TS, Perkins SN, Hursting SD, Young HA, Kim YS, Wang TC, Wang TT. Are you the author?
Laboratory of Cellular Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Reference: Int J Oncol. 2012 Apr;40(4):1113-21.
doi: 10.3892/ijo.2012.1335. Epub 2012 Jan 17.
PubMed Abstract
PMID: 22266918
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