BACKGROUND: The "New Western-style Diet" (NWD) characterized by high in fat and low in fiber, vitamin D, calcium, and methyl donors-are considered as a risk factor for prostate cancer. Previous studies have shown that premalignant lesions of human prostate have decreased expression of the Retinoid X Receptor alpha (RXRα). This study was to determine the effect of diet in RXRα knockout mice in developing high-grade prostate intraepithelial neoplasia (mPIN).
METHODS: Male mice (n = 54) with or without the RXRα prostate null mutation were fed either NWD or AIN-76A control diet for 10 months; prostates were harvested at 11 months of age and examined for prostate mPIN.
RESULTS: mPIN was seen in 79% of RXRα prostate null mice fed NWD (n = 19), 30.8% RXRα prostate null mice fed AIN-76A (n = 13), 42.9% RXRα wild-type mice fed NWD (n = 14), and 12.5% RXRα wild-type mice fed AIN-76A (n = 8). Unconditional Logistic analysis showed a significant joint effect of NWD and RXRα status in developing mPIN 26.3 (95% CI: 2.5-280), but interaction was not significant owing to the small sample size 1.6 (0.09-27.7, P = 0.7441).
CONCLUSION: This study provides preliminary data to support a joint RXRα-diet effect in prostate carcinogenesis.
Written by:
Mao GE, Harris DM, Moro A, Heber D, Roy-Burman P, Zhang ZF, Rao J Are you the author?
Center for Human Nutrition, UCLA School of Public Health, UCLA, Los Angeles, California; Department of Epidemiology, UCLA School of Public Health, UCLA, Los Angeles, California
Reference: Prostate. 2012 Jul 1;72(10):1052-9.
doi: 10.1002/pros.22496
PubMed Abstract
PMID: 22314496