Male reproductive failure has been linked to successive development of various urologic diseases including prostate cancer. There is strong epidemiologic data in support of this association, it is important therefore to identify the fundamental grounds that lay beneath such a connection. Male reproductive biology, as sex determined, is significantly dependent upon the hormonal regulation of androgens. With the advancement of knowledge on androgen receptivity and epigenetic regulation, the role of new regulatory factors such as microRNAs becomes essential. This review focuses on unraveling the role of microRNA tight incorporation in androgen-dependent male reproductive biology in the context of recent prostate cancer data.
Written by:
Todorova K, Mincheff M, Hayrabedyan S, Mincheva J, Zasheva D, Kuzmanov A, Fernández N Are you the author?
Institute of Biology and Immunology of Reproduction, BAS, Sofia, Bulgaria
Reference: Am J Reprod Immunol. 2012 Apr 26
doi: 10.1111/j.1600-0897.2012.01139.x
PubMed Abstract
PMID: 22537183