Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer.
Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN proto-oncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset.
Written by:
Aparicio A, Logothetis CJ, Maity SN. Are you the author?
Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA.
Reference: Cancer Discov. 2011 Nov;1(6):466-8.
PubMed Abstract
PMID: 22586648
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